Easy, Creamy Cajun Salmon Pasta

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This creamy cajun salmon pasta recipe is sure to become a new family favorite! This creamy pasta dish is made with tender chunks of salmon tossed with pasta in a creamy, slightly spicy sauce made with Cajun seasoning, garlic, cream, and Parmesan cheese. This dish is perfect for a cozy weeknight dinner, but also great for dinner guests or a special occasion!

Crazy for Cajun like me??! Try this Cajun Shrimp and Sausage Pasta, this delicious Cajun Chicken Spaghetti, this super easy Creamy Cajun Chicken Orzo, or this Cajun Fried Rice!

Close up of creamy Cajun salmon pasta on a spoon.

Pasta lovers–here’s a new one for your dinner table! This creamy salmon pasta is going to be a hit! Pasta of your choice is smothered in a creamy Cajun alfredo sauce and topped with perfectly cooked, fresh salmon.

This pasta dish can easily be customized to fit the spice tolerance of your family and you can even swap out the salmon for another type of fish, shrimp, or even chicken!

What you’ll love about this recipe:

  • JAZZ UP PASTA NIGHT – This recipe is a great way to try something different on pasta night!
  • FLAVORFUL CREAM SAUCE – Coats the pasta and complements the salmon perfectly!
  • EASY TO CUSTOMIZE – You can easily adapt this recipe to make it more or less spicy, as well as swap out the protein for chicken or another fish.
  • READY IN 30 MINUTES – Perfect for a busy weeknight!


You’ll need the following ingredients to make this Creamy Cajun Salmon Pasta Recipe:

Ingredients needed for cajun salmon pasta.


Salmon: I always prefer wild-caught, skinless salmon filets.

Cajun Seasoning: My favorite Cajun seasoning is Slap Ya Mama–it can usually be found in most larger chain grocery stores–and on Amazon, of course!. They have an Original blend, which is fairly mild, and also a HOT blend. You can also use Creole seasoning.

Pasta: I always tend to use spaghetti for this recipe, but any shape of pasta works just fine!


Here are some quick visual instructions. Remember that full instructions with exact ingredients will be in the recipe card below!

Step 1: Season salmon with Cajun seasoning. Place seasoned salmon in a hot pan and cook 3-4 minutes on each side. While salmon is cooking, boil pasta in a large pot of water until al dente. Drain and set aside {reserve about a 1/2 cup of the pasta water, if you remember!}.

Salmon filets cooking in a pan.

Step 2: Cook onions, peppers and garlic until slightly softened. Then, sprinkle flour over the veggies and cook one minute more.

Step 3: Add chicken broth, cream, and spices. Cook until slightly thick.

Bell peppers and onions cooking in a pan.
Creamy cajun alfredo sauce in a pan.

Step 4: After the salmon is cooked and slightly cool, break it into small pieces with a fork.

Salmon flaked with a fork on a white plate.

Step 5: Stir in Parmesan cheese, lemon juice/zest. Toss in pasta and salmon. Serve right away sprinkled with more Parmesan, a squeeze of lemon juice, and fresh parsley, if you like!

Creamy Cajun salmon pasta tossed with the salmon and spaghetti in the skillet.


  • Before you drain the pasta, reserve a 1/2 cup of the pasta water. You can use it to thin out your sauce, if needed.

  • If you have a bit of extra time, season your salmon fillets and let the salmon sit for 10-15 minutes to absorb the flavors.

Confidence Tip

If you have a meat thermometer you can test the internal temperature of your salmon to see if it’s cooked through. Internal temp should be 120-125°F. You can always just use a fork, too! If the salmon flakes easily, it’s done!


  • Storage: Store leftover Cajun salmon pasta in an airtight container in the fridge. I have found leftovers are best consumed the next day…if not eaten right after it’s been prepared! If possible, store cooked pasta and salmon separately.

  • Reheating: Reheat leftovers in the microwave on medium heat until warmed through.

  • Freezing: I do not recommend freezing this dish.
Close up photo of the creamy cajun pasta.

Additions & Substitutions


  • Spice it up: If your Cajun spice isn’t spicy enough for ya, add a dash of cayenne pepper or some hot sauce!
  • Tomatoes: Halved cherry tomatoes are a great addition, stirred in near the end. You can also you a can of diced tomatoes (drained).


  • Fish/Protein: You can use halibut or another firm white fish in place or salmon. This recipe is also great with chicken or shrimp!


What should I serve with this cajun salmon recipe?

This simple tossed green salad and some garlic bread are perfect sides for this dish! If you want more veggies, try this simple air fryer broccoli with parmesan.

How spicy is this dish?

This really depends on the spiciness of your Cajun seasoning. Most typical Cajun seasonings you find at the grocery store is on the milder side. My favorite is Slap Ya Mama–and they also have a HOT version as well!

Can I make this dish ahead of time?

I find this dish the very best if it’s enjoyed soon after it’s been prepared. Reheating salmon–although possible, is just never quite as yummy as it is freshly cooked!

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Easy Cajun alfredo pasta in the skillet ready to be served.

I hope you love this Cajun Salmon Pasta! If you make it be sure to leave a comment and a rating so I know how you liked it. Enjoy, xo!

closeup of salmon pasta on a fork

Easy, Creamy Cajun Salmon Pasta

Casey Rooney
This creamy cajun salmon pasta recipe that's sure to become a new family favorite! This creamy pasta dish is made with tender chunks of salmon tossed with pasta in a creamy, slightly spicy sauce made with Cajun seasoning, garlic, cream, and Parmesan cheese. This dish is perfect for a cozy weeknight dinner, but also great for dinner guests or a special occasion.
5 from 11 votes
Prep Time 15 minutes
Cook Time 15 minutes
Total Time 30 minutes
Course Dinner
Cuisine American
Servings 4
Calories 622 kcal


  • 16 oz. spaghetti (or your favorite pasta shape)
  • 1/2-1 lb. fresh salmon fillets I prefer skinless salmon fillets
  • 2 tbsp olive oil, divided
  • 1 medium yellow onion, diced
  • 1-2 cups bell peppers, chopped green or red bell pepper, or both!
  • 4-5 cloves fresh garlic, minced or a heaping tablespoon
  • 1 tbsp + 1 tsp Cajun or Creole seasoning
  • 2 tbsp flour
  • 1 cup chicken broth
  • 1 cup heavy cream
  • 1/2 cup Parmesan cheese, grated
  • 1 tsp onion powder
  • 1 tsp garlic powder
  • kosher salt/freshly ground black pepper to taste
  • juice of 1 lemon + 1 tsp lemon zest


  • Prep: Cook pasta to al dente, according to package directions. Drain and set aside. Tip: Reserve 1/2 cup or so of the starchy pasta water. You may need it later. While pasta is boiling, chop your onion and bell peppers.
  • Cook Salmon: In a large skillet, heat 1 tbsp of oil over medium-high heat. Pat salmon dry with a paper towel to remove any excess moisture. Then, season on both sides with 1 1/2 tsp of Cajun seasoning. Cook salmon 3-4 minutes on each side or until cooked through and flakes easily with a fork. Salmon should have a nice brown sear on each side. Remove and set aside.
  • Cook Veggies: To the same pan, heat remaining olive oil. Cook onion and bell pepper for 2-3 minutes until slightly soft. Add garlic and cook 1-2 minutes more. Sprinkle flour over everything and cook for one minute, stirring often.
  • Make the Creamy Sauce: Add chicken broth, cream and spices (garlic powder, onion powder, and remaining 1 tbsp of Cajun seasoning). Cook 3-4 minutes until sauce has thickened slightly. Add Parmesan cheese and stir until melted. Last, stir in lemon juice + zest. Taste, and season with salt and pepper if needed. Tip: If your sauce seems too thick, simply add a few splashes of your reserved pasta water.
  • Finish: Add spaghetti into the sauce and toss until well-coated. Break the cooked salmon into small pieces with a fork. Gently, toss salmon into the sauce. Serve right away topped with more Parmesan cheese and lemon juice, if you like!


Nutrition is only an estimate based on the Very Well Fit Nutrition Calculator
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Calories: 622kcalCarbohydrates: 53gProtein: 37gFat: 29.5gSaturated Fat: 11.2gCholesterol: 101mgSodium: 426mgPotassium: 761mgFiber: 3.1gSugar: 5gVitamin D: 16µgCalcium: 215mgIron: 2mg
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Recipe Rating


  1. 5 stars
    I absolutely love how the cajun seasoning works with the salmon; everything turns out so creamy and full of flavor. (So easy to make, too.) Thanks for this great recipe!